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IHC ATLAS

A collection of hand-selected
clinical breast cancer cases


Browse through whole slide images (WSIs) in the IHC image gallery, containing clinical cases, provided and consensus scored by the Pathology Faculty. Contribute to the community polling with the What’s your interpretation? tool for featured clinical cases.

Brought to you by the Pathology Faculty
Brought to you by the Pathology Faculty

Members of the Breast Pathology Faculty have been contracted as paid advisors through Daiichi Sankyo and AstraZeneca, and have received compensation for their time.

EXPLORE CLINICAL CASES

IHC image gallery

Explore the collection of hand-selected clinical cases, organized within categories. Click on each thumbnail to enlarge the image and select View whole slide image to inspect the WSI in detail.

  1. Challenging staining patterns
  2. Non-specific staining patterns/artifacts
  3. Non-consensus scored clinical cases
  4. Non-challenging staining patterns

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PRACTICE SCORING

What's your interpretation?

Click through the image carousel, view the WSIs, and select your HER2 IHC score. Submit to see how your score compared to others or simply ‘reveal poll’.

Her2 - 1.ndpi

Total Cases 1 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Her2 - 2.ndpi

Total Cases 2 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Her2 - 3.ndpi

Total Cases 3 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Her2 - 4.ndpi

Total Cases 4 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Her2 - 5.ndpi

Total Cases 5 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

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Her2 - 6.ndpi

Total Cases 6 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Her2 - 8.ndpi

Total Cases 7 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Her2 - 10.ndpi

Total Cases 8 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Her2 - 15.ndpi

Total Cases 9 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

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Her2 - 16.ndpi

Total Cases 10 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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Her2 - 18.ndpi

Total Cases 11 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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Her2 - 20.ndpi

Total Cases 12 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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Her2 - 23.ndpi

Total Cases 13 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Her2 - 28.ndpi

Total Cases 14 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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Her2 - 25.ndpi

Total Cases 15 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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Her2 - 30.ndpi

Total Cases 16 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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Her2 - 26.ndpi

Total Cases 17 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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Her2 - 29.ndpi

Total Cases 18 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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Her2 - 31.ndpi

Total Cases 19 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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SK_C11HER2

Total Cases 20 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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SK_C12HER2

Total Cases 21 OF 21

Dr. Michael Feldman Vice Chair of Clinical Services, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Invasive breast carcinoma

Which HER2 IHC score would you assign to this slide?

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Submitted Score

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Mobile View Text

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All patient identifiable information has been removed to maintain patient privacy. The facts of this case are based on actual medical cases, but the case and information provided are offered solely for educational purposes. The information presented is not offered as, nor does it represent, consultation or second opinion.

Supporting Resources

A growing suite of peer-developed educational material and resources to support good clinical practice of IHC assessment in breast cancer across the spectrum of HER2 expression.

View resources

HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; IPLC, invasive pleomorphic lobular carcinoma; NST, non-special type; WSI, whole slide image.

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This website is intended to help healthcare professionals practicing in Malaysia. find and access scientifically balanced, evidence-based, and peer-led information and professional resources in support of HER2 IHC evaluation in breast cancer.

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This information is provided for educational purposes only. It is not intended for use in the diagnosis or treatment of individual patients.

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